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ZAP-70
Method
Units
Reference Range
Flow Cytometry
Negative, Positive
Positive
Specimen Requirements
Preferred
No
Type
Volume
Temperature/Stability
1
Bone marrow sodium heparin (green top) and 1 smear from specimen
4 mL
Room temperature; for overnight storage refrigerate; transport with refrigerated cold pack
Alternate
No
Type
Volume
Temperature/Stability
1
Whole blood sodium heparin (green top)
4 mL
Room temperature; for overnight storage refrigerate; transport with refrigerated cold pack
2
Bone marrow or whole blood ACD (yellow top)
4 mL
Room temperature; for overnight storage refrigerate; transport with refrigerated cold pack
General Information
Clinical Utility
Determination of ZAP-70 status of chronic lymphocytic leukemia patients. Positive ZAP-70 correlates with unmutatead IgVH gene status and an unfavorable prognosis.
Set Up Schedule
Monday-Saturday
Turnaround Time
12-24 hours
CPT Codes
88185 (in combination with other markers used for the identification of the neoplastic population)
FDA Status
Laboratory developed test
Notes
References
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